STUDY TO KNOW THE ASSOCIATION BETWEEN LOW MATERNAL SERUM VITAMIN "D" LEVELS AND GESTATIONAL DIABETES MELLITUS

Background: The deficiency of maternal vitamin D is more critical during pregnancy. Maternal vitamin D status has directly relation with gestational diabetes mellitus (GDM. The aim of this study is to determine the relationship between low maternal serum vitamin d levels and gestational diabetes mellitus. Study Design: This is a cross-sectional study, conducted in the department of obstetrics and gynecology of Mayo Hospital Lahore for the duration of one year from January 2019 to January 2020. Materials and Methods: 140 pregnant women were included in this study. Out of 140 subjects, 70 women already diagnosed with GDM were taken as cases and 70 normal pregnant women were taken as control. All the patients included were subjected to detailed history taking. Blood samples were taken from both cases and control and sent for Vitamin-D level, HbA1c, Fasting blood glucose and 2hrs postprandial glucose test. Results: An attempt has been made to assess the association of maternal serum vitamin D with Gestational diabetes mellitus and also to see its relation with glycemic control in patients with GDM. Overall 71% women are vitamin D deficient in our study. The mean maternal serum vitamin D levels were 8.83 ± 5.77ng/ml in Group A and 17.04 ± 8.67ng/ml in group B. The difference was statistically significant reflecting that the mean serum vitamin D was decreased in women with GDM. (P value=0.001). Conclusions: Low maternal serum vitamin D levels were associated with gestational diabetes mellitus. There is a statistically significant negative correlation between the glycemic control and vitamin D levels in serum in the whole study population. Keywords: vitamin D levels, gestational diabetes mellitus, maternal serum